SANS has been kind enough to post a paper that I wrote targeted at the end-user titles “Top Five Tips to Prevent Malware”. I believe it is important to break it down for the end-user into short tips that they can do, which are:
1) Don’t use Internet Explorer For General Web Browsing
2) Run as a non-privileged user
3) Run an Anti-Virus program
4) Use Anti-Spyware tools
5) Patch and upgrade your system often
This paper is a good read for those who do not have total control over the desktop machines in your environment and want something to send to their users, have users who use their home machine to VPN into the office, or to send to friends and family to help keep them from unknowingly participating in botnets.
You can find the paper in the SANS Reading Room in the Special Topics section:
http://www.sans.org/rr/special/index.php?id=preventmalware
As always, feel free to send me you comments/feedback (paul /at/ pauldotcom.com)
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About the author

Paul Asadoorian is the Founder & CEO of Security Weekly, where the flagship show recently re-titled "Paul's Security Weekly" has been airing for over 8 years. By day he is the Product Evangelist for Tenable Network Security. Paul produces and hosts the various shows here at Security Weekly, all dedicated to providing the latest security news, interviews with the industries finest and technical how-to segments. Paul is also the founder and host of "The Stogie Geeks Show", featuring cigar reviews for cigar enthusiasts.